Effect of Ethanol on Iontophoretic Transdermal Delivery of 5-Aminolevulinic Acid through Yucatan Micropig Full-thickness Skin
By: Asai, Kazusa
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Contributor(s): Ochiai, A | Kawashima, N.
Publisher: Mumbai Indian Journal of Pharmaceutical Science 2019Edition: Vol. 81(1), Jan-Feb.Description: 177-181p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian journal of pharmaceutical sciencesSummary: The effect of ethanol was investigated on iontophoretic transdermal delivery of 5-aminolevulinic acid through Yucatan micropig full-thickness skin. When 20 % ethanol was added into an aqueous 5-aminolevulinic acid solution, the iontophoretic permeation of 5-aminolevulinic acid through Yucatan micropig full-thickness skin was enhanced. The addition of ethanol also enlarged the partition of 5-aminolevulinic acid into Yucatan micropig full-thickness skin, which gave rise to enhancement of 5-aminolevulinic acid permeation. This result suggested that the combination system of iontophoretic delivery and 20 % ethanol could be a promising approach for the promotion of 5-aminolevulinic acid skin permeation.Key words: Iontophoresis, 5-aminolevulinic acid, ethanol, Yucatan micropig full-thickness skin, permeability coefficient, diffusion coefficient, partition coefficient, lag time
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Articles Abstract Database
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School of Pharmacy Archieval Section | Not for loan | 2018519 |
The effect of ethanol was investigated on iontophoretic transdermal delivery of 5-aminolevulinic acid through Yucatan micropig full-thickness skin. When 20 % ethanol was added into an aqueous 5-aminolevulinic acid solution, the iontophoretic permeation of 5-aminolevulinic acid through Yucatan micropig full-thickness skin was enhanced. The addition of ethanol also enlarged the partition of 5-aminolevulinic acid into Yucatan micropig full-thickness skin, which gave rise to enhancement of 5-aminolevulinic acid permeation. This result suggested that the combination system of iontophoretic delivery and 20 % ethanol could be a promising approach for the promotion of 5-aminolevulinic acid skin permeation.Key words: Iontophoresis, 5-aminolevulinic acid, ethanol, Yucatan micropig full-thickness skin, permeability coefficient, diffusion coefficient, partition coefficient, lag time
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